Pesquisa sobre:
PLECKSTRIN HOMOLOGY DOMAINS
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DeCS
Descritor
Inglês
:
Pleckstrin Homology Domains
Descritor
Espanhol
:
Dominios Homólogos a Pleckstrina
Descritor
Português
:
Domínios de Homologia à Plecstrina
Sinônimos
Inglês
:
PH Domain
PH Domains
Pleckstrin Homology Domain
Domain, PH
Domain, Pleckstrin Homology
Domains, PH
Domains, Pleckstrin Homology
Homology Domain, Pleckstrin
Homology Domains, Pleckstrin
Categoria:
G02.111.570.820.709.275.750.469
Definição
Inglês
:
Protein domains
of approximately 120
amino acids
that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING
PROTEINS
and
CYTOSKELETAL PROTEINS
where they bind
PHOSPHATIDYLINOSITOLS
within the
CELL MEMBRANE
and
INTRACELLULAR MEMBRANES
, as well as
proteins
that include the Betagamma-subunits of
HETEROTRIMERIC GTP-BINDING PROTEINS
, and
PROTEIN KINASE C
. These interactions allow the targeting of
proteins
to different cellular compartments and
SIGNAL TRANSDUCTION
PATHWAYS.
Nota Histórica
Inglês
:
2017
Qualificadores Permitidos
Inglês
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Número do Registro:
56742
Identificador Único:
D000070539
Ocorrência na BVS
:
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